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Introduction Stroke, caused by a sudden interruption to the blood supply of the brain, has a wide range of detrimental consequences that have contributed to its recognition as the leading cause of disability and second most common cause of death worldwide

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The provision of high-energy phosphates through mitochondrial substrate-level phosphorylation (mtSLP, Fig

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The COX and LOX pathways are the primary routes for metabolizing AA into inflammatory mediators and breaking it down into leukotrienes, prostaglandins, and some peroxides [58]